POY 2024

Below is a collection of the papers that we were most excited about in 2024.

	Title	journal
0	1,4‐Aminoarylation of Butadienes via Photoinduced Palladium Catalysis	ACIE
1	β‐Phenethylamine Synthesis: N‐Pyridinium Aziridines as Latent Dual Electrophiles	ACIE
2	A General Iron‐Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids	ACIE
3	A Rationally Designed Iron(II) Catalyst for C(sp³)−C(sp²) and C(sp³)−C(sp³) Suzuki–Miyaura Cross‐Coupling	ACIE
4	Asymmetric Dearomatization of Indoles through Cobalt‐Catalyzed Enantioselective C−H Functionalization Enabled by Photocatalysis	ACIE
5	Cationic Bis(hydrosilane)—Coinage‐Metal Complexes: Synthesis, Characterization, and Use as Catalysts for Outer‐Sphere C=O Hydrosilylation Not Involving Metal Hydrides	ACIE
6	Chemoselective and Stereoselective Allylation of Bis(alkenyl)boronates	ACIE
7	Conformational Locking Induced Enantioselective Diarylcarbene Insertion into B−H and O−H Bonds Using a Cationic Rh(I)/Diene Catalyst	ACIE
8	Construction of Bridged Benzazepines via Photo‐Induced Dearomatization	ACIE
9	Copper‐Catalyzed Regiodivergent Asymmetric Difunctionalization of Terminal Alkynes	ACIE
10	Copper‐Catalyzed α‐Arylation of Nitroalkanes with (Hetero)aryl Bromides/Iodides	ACIE
11	Deconstructive Carboxylation of Activated Alkenes with Carbon Dioxide	ACIE
12	Deoxygenative Transformation of Alcohols via Phosphoranyl Radical from Exogenous Radical Addition	ACIE
13	Dual‐Catalysed Intermolecular Reductive Coupling of Dienes and Ketones**	ACIE
14	Dynamic Asymmetric Diamination of Allylic Alcohols through Borrowing Hydrogen Catalysis: Diastereo‐Divergent Synthesis of Tetrahydrobenzodiazepines	ACIE
15	Enantioconvergent Cross‐Nucleophile Coupling: Copper‐Catalyzed Deborylative Cyanation	ACIE
16	Enantioconvergent Negishi Cross‐Couplings of Racemic Secondary Organozinc Reagents to Access Privileged Scaffolds: A Combined Experimental and Theoretical Study	ACIE
17	Expansion of Structure Property in Cascade Nazarov Cyclization and Cycloexpansion Reaction to Diverse Angular Tricycles and Total Synthesis of Nominal Madreporanone	ACIE
18	Exploring Superacid‐Promoted Skeletal Reorganization of Aliphatic Nitrogen‐Containing Compounds	ACIE
19	Intramolecular Carboamination of Aminodienes to N‐Heterocycles via C−N Bond Activation	ACIE
20	Modular and Diverse Synthesis of Acrylamides by Palladium‐Catalyzed Hydroaminocarbonylation of Acetylene	ACIE
21	Molecular Editing of Pyrroles to Benzenes/Naphthalenes by N₂O Deletion.	ACIE
22	New Frontiers in Organosodium Chemistry as Sustainable Alternatives to Organolithium Reagents	ACIE
23	Olefination of Aromatic Carbonyls via Site‐Specific Activation of Cycloalkanone Ketals**	ACIE
24	One‐Carbon Ring Expansion of Indoles and Pyrroles: A Straightforward Access to 3‐Fluorinated Quinolines and Pyridines	ACIE
25	Palladium(0) and Brønsted Acid Co‐Catalyzed Enantioselective Hydro‐Cyclization of 2,4‐Dienyl Hydrazones and Oximes	ACIE
26	Palladium‐Catalyzed Deuteration of Arylketone Oxime Ethers	ACIE
27	Photochemical Deoxygenative Hydroalkylation of Unactivated Alkenes Promoted by a Nucleophilic Organocatalyst	ACIE
28	Photoexcitation of Distinct Divalent Palladium Complexes in Cross‐Coupling Amination Under Air	ACIE
29	Photoinduced Cu(II)‐Mediated Decarboxylative Thianthrenation ofAryl and Heteroaryl Carboxylic Acids	ACIE
30	Photoredox‐Catalyzed Generation of Tertiary Anions from Primary Amines via a Radical Polar Crossover	ACIE
31	Photoredox‐Catalyzed α−C−H Monoalkylation of Symmetric Polyols in the Presence of CO₂	ACIE
32	Regio‐ and Diastereoselective Synthesis of Polysubstituted Piperidines Enabled by Boronyl Radical‐Catalyzed (4+2) Cycloaddition	ACIE
33	Rhodium‐Catalyzed Asymmetric Cyclopropanation of Indoles with N‐Triftosylhydrazones	ACIE
34	Ring Contraction of Saturated Cyclic Amines and Rearrangement of Acyclic Amines Through Their Corresponding Hydroxylamines	ACIE
35	Second Generation Catalytic Enantioselective Nucleophilic Desymmetrization at Phosphorus (V): Improved Generality, Efficiency and Modularity	ACIE
36	Selective Cross‐Metathesis Versus Ring‐Closing Metathesis of Terpenes, Taking the Path Less Travelled	ACIE
37	Site‐Selective Activation and Stereospecific Functionalization of Bis(boronic Esters) Derived from 2‐Alkenes: Construction of Propionates and Other 1,2‐Difunctional Motifs	ACIE
38	Site‐Specific Deaminative Trifluoromethylation of Aliphatic Primary Amines**	ACIE
39	Site‐selective Photoredox‐Catalyzed Late‐stage Benzylic Hydrogen Isotope Exchange	ACIE
40	Skeletal Editing of Aromatic N‐Heterocycles via Hydroborative Cleavage of C−N Bonds—Scope, Mechanism, and Property	ACIE
41	Spiro[3.3]heptane as a Saturated Benzene Bioisostere**	ACIE
42	Stereodivergency in Copper‐Catalyzed Borylative Difunctionalizations: The Impact of Boron Coordination	ACIE
43	Stereoselective Copper‐Catalyzed Olefination of Imines	ACIE
44	Stereoselective C−B and C−H Bonds Functionalization of PolyBorylated Alkenes	ACIE
45	Streamlining the Synthesis of Pyridones through Oxidative Amination of Cyclopentenones	ACIE
46	Sulfonium Rearrangements Enable the Direct Preparation of Sulfenyl Imidinium Salts	ACIE
47	The Synthesis and Reactivity of Naphthoquinonynes	ACIE
48	Total Synthesis of Lissodendoric Acid A	ACIE
49	Traceless Nucleophile Strategy for C5‐Selective C−H Sulfonylation of Pyridines	ACIE
50	Unlocking the Asymmetric Hydrogenation of Tetrasubstituted Acyclic Enones	ACIE
51	Vitamin B₁₂‐Photocatalyzed Cyclopropanation of Electron‐Deficient Alkenes Using Dichloromethane as the Methylene Source**	ACIE
52	Werner Salt as Nickel and Ammonia Source for Photochemical Synthesis of Primary Aryl Amines	ACIE
53	Acid-Catalyzed Oxy-aminomethylation of Styrenes	ACS Catal.
54	Cross-Coupling Reactions with Nickel, Visible Light, and tert-Butylamine as a Bifunctional Additive	ACS Catal.
55	Intermolecular Anti-Markovnikov Hydroamination of Alkenes with Sulfonamides, Sulfamides, and Sulfamates	ACS Catal.
56	Recent Advances in Catalytic Nitrogen–Nitrogen Bond Formation Reactions	ACS Catal.
57	Reductive Olefin Bicyclo[1.1.0]butane Coupling Enabled by Iron Hydride Hydrogen Atom Transfer	ACS Catal.
58	Ti-Catalyzed Oxidative Amination Using Anilines	ACS Catal.
59	Selective 1,4-syn-Addition to Cyclic 1,3-Dienes via Hybrid Palladium Catalysis	ACS Central Science
60	Visible Light instead of Transition Metal: Electron Donor Acceptor Complex Enabled Cross‐Coupling of Aryl Halides with Active Methylene Compounds	Adv. Synth. Catal.
61	Aluminium porphyrins catalyse the hydrogenation of CO₂ with H₂	Chem. Sci.
62	Boryl radical-mediated halogen-atom transfer (XAT) enables the Sonogashira-like alkynylation of alkyl halides	Chem. Sci.
63	Exploring the molecular design principles for efficient diarylethene photoacid and photohydride generators based on the photochemical reaction mechanism	Chem. Sci.
64	Nitrogen atom insertion into arenols to access benzazepines	Chem. Sci.
65	Photocatalytic (3 + 2) dipolar cycloadditions of aziridines driven by visible-light	Chem. Sci.
66	Photocatalytic, modular difunctionalization of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer	Chem. Sci.
67	Transfer learning for a foundational chemistry model	Chem. Sci.
68	Anti-selective Cyclopropanation of Nonconjugated Alkenes with Diverse Pronucleophiles via Directed Nucleopalladation	JACS
69	¹⁴N to ¹⁵N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing	JACS
70	¹⁵NRORC: An Azine Labeling Protocol	JACS
71	A Bimolecular Homolytic Substitution-Enabled Platform for Multicomponent Cross-Coupling of Unactivated Alkenes	JACS
72	A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes	JACS
73	A General Platform for Visible Light Sulfonylation Reactions Enabled by Catalytic Triarylamine EDA Complexes	JACS
74	A General Strategy for N-(Hetero)arylpiperidine Synthesis Using Zincke Imine Intermediates	JACS
75	A General Synthetic Strategy toward the Truxillate Natural Products via Solid-State Photocycloadditions	JACS
76	A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions	JACS
77	A Radical Strategy for the Alkylation of Amides with Alkyl Halides by Merging Boryl Radical-Mediated Halogen-Atom Transfer and Copper Catalysis	JACS
78	A Strain-Promoted Divergent Chemical Steroidation Unveils Potent Anti- Inflammatory Pseudo-Steroidal Glycosides	JACS
79	A Type of Chiral C₂-Symmetric Arylthiol Catalyst for Highly Enantioselective Anti-Markovnikov Hydroamination	JACS
80	Alkene Hydrobenzylation by a Single Catalyst That Mediates Iterative Outer-Sphere Steps	JACS
81	Alkoxy Radical Generation Mediated by Sulfoxide Cation Radicals for Alcohol-Directed Aliphatic C–H Functionalization	JACS
82	Alkynes to (Free) Carbenes to Polycyclic Cyclopropanes	JACS
83	An Azide-Free Synthesis of Metallodiazomethanes Using Nitrous Oxide	JACS
84	Aziridine Group Transfer via Transient N-Aziridinyl Radicals	JACS
85	Bicyclo[2.2.0]hexene: A Multicyclic Mechanophore with Reactivity Diversified by External Forces	JACS
86	Borane-Catalyzed Enantioselective α-Alkylation of Unactivated 2-Alkylbenzoxazoles with Electron-Deficient Olefins	JACS
87	C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of Pyridine N-Oxides	JACS
88	Carboiodanation of Arynes: Organoiodine(III) Compounds as Nucleophilic Organometalloids	JACS
89	Catalytic Asymmetric Barbier Reaction of Ketones with Unactivated Alkyl Electrophiles	JACS
90	Catalytic Asymmetric Construction of Chiral Polysubstituted 3-Azabicyclo[3.1.1]heptanes by Copper-Catalyzed Stereoselective Formal [4π+2σ] Cycloaddition	JACS
91	Catalytic Asymmetric Cycloaddition of Olefins with In Situ Generated N-Boc-Formaldimine	JACS
92	Catalytic Enantioselective Nucleophilic α-Chlorination of Ketones with NaCl	JACS
93	Catalytic Intermolecular Deoxygenative Coupling of Carbonyl Compounds with Alkynes by a Cp*Mo(II)-Catalyst	JACS
94	Catalytic Regio- and Enantioselective Boracarboxylation of Arylalkenes with CO₂ and Diboron	JACS
95	Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine	JACS
96	Chiral Brønsted Acid-Catalyzed Intramolecular Asymmetric Dearomatization Reaction of Indoles with Cyclobutanones via Cascade Friedel–Crafts/Semipinacol Rearrangement	JACS
97	Cobalt-Catalyzed Asymmetric Hydrogenation of Ketones Enabled by the Synergism of an N–H Functionality and a Redox-Active Ligand	JACS
98	Computational Design of Ligands for the Ir-Catalyzed C5-Borylation of Indoles through Tuning Dispersion Interactions	JACS
99	Computational Methods Enable the Prediction of Improved Catalysts for Nickel-Catalyzed Cross-Electrophile Coupling	JACS
100	Computationally Guided Ligand Discovery from Compound Libraries and Discovery of a New Class of Ligands for Ni-Catalyzed Cross- Electrophile Coupling of Challenging Quinoline Halides	JACS
101	Construction of Vicinal Quaternary Centers via Ru-Catalyzed Enantiospecific Allylic Substitution with Lithium Ester Enolates	JACS
102	Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin Hydroamination	JACS
103	Copper(I)-Catalyzed Enantioselective α-Alkylation of 2-Acylimidazoles	JACS
104	Copper-Catalyzed Amination of Aryl Chlorides under Mild Reaction Conditions	JACS
105	Copper–Nitroxyl-Catalyzed α-Oxygenation of Cyclic Secondary Amines Including Application to Late-Stage Functionalization	JACS
106	Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals	JACS
107	Dearomatization of Pyridines: Photochemical Skeletal Enlargement for the Synthesis of 1,2-Diazepines	JACS
108	Development of a Deactivation-Resistant Dialkylbiarylphosphine Ligand for Pd-Catalyzed Arylation of Secondary Amines	JACS
109	Development of a General Organophosphorus Radical Trap: Deoxyphosphonylation of Alcohols	JACS
110	Difluorocarbene Generation via a Spin-Forbidden Excitation under Visible Light Irradiation	JACS
111	Direct Bioisostere Replacement Enabled by Metallaphotoredox Deoxydifluoromethylation	JACS
112	Direct C–H Hydroxylation of N-Heteroarenes and Benzenes via Base-Catalyzed Halogen Transfer	JACS
113	Direct Enantioselective α-C–H Conjugate Addition of Propargylamines to α,β-Unsaturated Ketones via Carbonyl Catalysis	JACS
114	Divergent Synthesis of Scabrolide A and Havellockate via an exo-exo-endo Radical Cascade	JACS
115	Double Strain-Release [2π+2σ]-Photocycloaddition	JACS
116	Dual Ligand Enabled Pd-Catalyzed Ortho-Alkylation of Iodoarenes	JACS
117	Electrochemistry-Enabled C-Heteroatom Bond Formation of Alkyl Germanes	JACS
118	Enantioselective Alkylation of Primary C(sp³)–H Bonds in N-Methyl Tertiary Amine Enabled by Iridium Complex of Axially Chiral β-Aryl Porphyrins	JACS
119	Enantioselective Aziridination of Unactivated Terminal Alkenes Using a Planar Chiral Rh(III) Indenyl Catalyst	JACS
120	Enantioselective Carbon Isotope Exchange	JACS
121	Enantioselective Carbonylative Cyclization of Alkenes with C–H Bonds for Synthesis of γ-Lactams Bearing an α-Quaternary Carbon	JACS
122	Enantioselective Nickel-Electrocatalyzed Cross-Dehydrogenative α- and γ-Nitroalkylation	JACS
123	Enantioselective Potassium-Catalyzed Wittig Olefinations	JACS
124	Fe/Thiol Cooperative Hydrogen Atom Transfer Olefin Hydrogenation: Mechanistic Insights That Inform Enantioselective Catalysis	JACS
125	Formal meta-C–H-Fluorination of Pyridines and Isoquinolines through Dearomatized Oxazinopyridine Intermediates	JACS
126	Formal [2σ + 2σ]-Cycloaddition of Aziridines with Bicyclo[1.1.0]butanes: Access to Enantiopure 2-Azabicyclo[3.1.1]heptane Derivatives	JACS
127	From Methane to Methanol: Pd-iC-CeO₂ Catalysts Engineered for High Selectivity via Mechanochemical Synthesis	JACS
128	General Installation of (4H)-Imidazolone cis-Amide Bioisosteres Along the Peptide Backbone	JACS
129	General Regio- and Diastereoselective Allylic C–H Oxygenation of Internal Alkenes	JACS
130	Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction	JACS
131	Harnessing Oxetane and Azetidine Sulfonyl Fluorides for Opportunities in Drug Discovery	JACS
132	Incorporating Synthetic Accessibility in Drug Design: Predicting Reaction Yields of Suzuki Cross-Couplings by Leveraging AbbVie’s 15-Year Parallel Library Data Set	JACS
133	Iridium-Catalyzed Enantioconvergent Construction of Piperidines and Tetrahydroisoquinolines from Racemic 1,5-Diols	JACS
134	Iron-Catalyzed Cross-Electrophile Coupling for the Formation of All- Carbon Quaternary Centers	JACS
135	Iron-Catalyzed Primary Amination of C(sp³)–H Bonds	JACS
136	Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enable the Selective Synthesis of Benzestrol Isomers	JACS
137	Iterative One-Carbon Homologation of Unmodified Carboxylic Acids	JACS
138	Kinetic Modeling Enables Understanding of Off-Cycle Processes in Pd- Catalyzed Amination of Five-Membered Heteroaryl Halides	JACS
139	Late-Stage Saturation of Drug Molecules	JACS
140	Ligand-Controlled Cobalt-Catalyzed Regio-, Enantio-, and Diastereoselective Oxyheterocyclic Alkene Hydroalkylation	JACS
141	Mechanistic Investigation, Wavelength-Dependent Reactivity, and Expanded Reactivity of N–Aryl Azacycle Photomediated Ring Contractions	JACS
142	Merging Organocatalysis with 1,2-Boronate Rearrangement: A Lewis Base- Catalyzed Asymmetric Multicomponent Reaction	JACS
143	Metallomimetic C–F Activation Catalysis by Simple Phosphines	JACS
144	Modular Access to Functionalized Oxetanes as Benzoyl Bioisosteres	JACS
145	Modular, Enantioselective Entry into Polysubstituted Shapeshifting Molecules	JACS
146	Multicomponent Construction of Tertiary Alkylamines by Photoredox/Nickel-Catalyzed Aminoalkylation of Organohalides	JACS
147	Multicomponent Synthesis of α-Branched Amines via a Zinc-Mediated Carbonyl Alkylative Amination Reaction	JACS
148	Multielectron Reduction of Esters by a Diazabenzacenaphthenium Photoredox Catalyst	JACS
149	Multifunctionalization of Alkenyl Alcohols via a Sequential Relay Process	JACS
150	Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides	JACS
151	Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas	JACS
152	Nickel-Catalyzed Enantioselective C(sp³)–C(sp³) Cross-Electrophile Coupling of N-Sulfonyl Styrenyl Aziridines with Alkyl Bromides	JACS
153	Nickel-Catalyzed Hydrofluorination in Unactivated Alkenes: Regio- and Enantioselective C–F Bond Formation	JACS
154	Non-Innocent Role of Sacrificial Anodes in Electrochemical Nickel- Catalyzed C(sp²)–C(sp³) Cross-Electrophile Coupling	JACS
155	Oxidative Dearomatization of Pyridines	JACS
156	Oxidative Nitrogen Insertion into Silyl Enol Ether C═C Bonds	JACS
157	Oxoammonium-Catalyzed Oxidation of N-Substituted Amines	JACS
158	Palladium-Catalyzed Amination of Aryl Halides with Aqueous Ammonia and Hydroxide Base Enabled by Ligand Development	JACS
159	Pd/Cu-Cocatalyzed Enantio- and Diastereodivergent Wacker-Type Dicarbofunctionalization of Unactivated Alkenes	JACS
160	Photoredox Nucleophilic (Radio)fluorination of Alkoxyamines	JACS
161	Practical Synthesis of Chiral α-Aminophosphonates with Weak Bonding Organocatalysis at ppm Loading	JACS
162	Programmable Piperazine Synthesis via Organic Photoredox Catalysis	JACS
163	Radical Replacement Process for Ligated Boryl Radical-Mediated Activation of Unactivated Alkyl Chlorides for C(sp³)–C(sp³) Bond Formation	JACS
164	Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass Spectrometry	JACS
165	Red Light–Blue Light Chromoselective C(sp²)–X Bond Activation by Organic Helicenium-Based Photocatalysis	JACS
166	Redox-Neutral, Iron-Mediated Directed C–H Activation: General Principles and Mechanistic Insights	JACS
167	Reductive Cyclopropanation through Bismuth Photocatalysis	JACS
168	Regiodivergent Ring-Expansion of Oxindoles to Quinolinones	JACS
169	Regioselective Pyridine to Benzene Edit Inspired by Water-Displacement	JACS
170	Remote C–H Amination and Alkylation of Camphor at C8 through Hydrogen- Atom Abstraction	JACS
171	Rhodium-Catalyzed Asymmetric Reductive Hydroformylation of α-Substituted Enamides	JACS
172	Silyl Radicals as Single-Electron Reductants: α-Aminoalkyl Radical Formation via a Photocatalytic Oxidatively Initiated Radical Chain Process	JACS
173	Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni- Electrocatalytic Decarboxylative Arylation	JACS
174	Simultaneous Stereoinvertive and Stereoselective C(sp³)–C(sp³) Cross-Coupling of Boronic Esters and Allylic Carbonates	JACS
175	Stereodivergent Synthesis of 1,4-Dicarbonyl Compounds through Sulfonium Rearrangement: Mechanistic Investigation, Stereocontrolled Access to γ-Lactones and γ-Lactams, and Total Synthesis of Paraconic Acids	JACS
176	Stereospecific Phosphination and Thioetherification of Organoboronic Esters	JACS
177	Sustainable Aerobic Allylic C–H Bond Oxidation with Heterogeneous Iron Catalyst	JACS
178	Switchable Decarboxylation by Energy- or Electron-Transfer Photocatalysis	JACS
179	Switchable and Chemoselective Arene Hydrogenation for Efficient Late Stage Applications	JACS
180	Synthesis and Suzuki–Miyaura Cross-Coupling of Alkyl Amine-Boranes. A Boryl Radical-Enabled Strategy	JACS
181	Synthesis of ¹⁵N-Pyridines and Higher Mass Isotopologs via Zincke Imine Intermediates	JACS
182	Total Synthesis Facilitates In Vitro Reconstitution of the C–S Bond-Forming P450 in Griseoviridin Biosynthesis	JACS
183	Total Synthesis of Putative Melognine	JACS
184	Versatile, Modular, and General Strategy for the Synthesis of α-Amino Carbonyls	JACS
185	Vinyltriarylbismuthonium Salts: Powerful Vehicles for α-Vinylation of Carbonyl Compounds	JACS
186	Visible-Light Photocatalytic C–H Amination of Arenes Utilizing Acridine–Lewis Acid Complexes	JACS
187	Visible-Light-Mediated Vicinal Dihalogenation of Unsaturated C–C Bonds Using Dual-Functional Group Transfer Reagents	JACS
188	Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility	JMC
189	Fentanyl-Type Antagonist of the μ-Opioid Receptor: Important Role of Axial Chirality in the Active Conformation	JMC
190	MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery	JMC
191	A 21st Century View of Allowed and Forbidden Electrocyclic Reactions	JOC
192	Accessing Highly Substituted Indoles via B(C₆F₅)₃-Catalyzed Secondary Alkyl Group Transfer	JOC
193	Construction of Seven-Membered Oxacycles Using a Rh(I)-Catalyzed Cascade C–C Formation/Cleavage of Cyclobutenol Derivatives	JOC
194	Metal-Free Synthesis of 4-Bromoisoquinolines through Brominative Annulation of 2-Alkynyl Arylimidate Using In Situ-Generated Transient Bromoiodane	JOC
195	Organocatalytic Decarboxylative Borylation of Cyclopropane N-Hydroxyphthalimide Esters	JOC
196	Oxygenation of Phenols with Water as the Oxygen Source and Oxoammonium Salt as the Oxidant	JOC
197	Photocatalyzed Amination of Alkyl Halides to Access Primary Amines	JOC
198	Ring Opening of N-Acyl Lactams Using Nickel-Catalyzed Transamidation	JOC
199	Visible Light Mediated Chemoselective Hydroxylation of Benzylic Methylenes	JOC
200	α-Acyloxylation of Ketones/Cyclic Ethers Mediated by Hypervalent Iodine(III) Reagents as Oxidants and Nucleophilic Sources	JOC
201	C–heteroatom coupling with electron-rich aryls enabled by nickel catalysis and light	Nat. Cat.
202	Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C–H bond activation	Nat. Cat.
203	Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides	Nat. Cat.
204	Photocatalytic generation of alkyl carbanions from aryl alkenes	Nat. Cat.
205	Photoredox-catalysed amidyl radical insertion to bicyclo[1.1.0]butanes	Nat. Cat.
206	Radical strain-release photocatalysis for the synthesis of azetidines	Nat. Cat.
207	Ring expansion of indene by photoredox-enabled functionalized carbon- atom insertion	Nat. Cat.
208	The iron-catalysed Suzuki coupling of aryl chlorides	Nat. Cat.
209	A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution	Nat. Chem.
210	A para- to meta-isomerization of phenols	Nat. Chem.
211	Asymmetric dearomative single-atom skeletal editing of indoles and pyrroles	Nat. Chem.
212	Bridging the information gap in organic chemical reactions	Nat. Chem.
213	Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis	Nat. Chem.
214	Cobalt-catalysed desymmetrization of malononitriles via enantioselective borohydride reduction	Nat. Chem.
215	Discovery of N–X anomeric amides as electrophilic halogenation reagents	Nat. Chem.
216	Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion	Nat. Chem.
217	Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines	Nat. Chem.
218	Enantioselective construction of stereogenic-at-sulfur(IV) centres via catalytic acyl transfer sulfinylation	Nat. Chem.
219	Enantiospecific cross-coupling of cyclic alkyl sulfones	Nat. Chem.
220	Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release	Nat. Chem.
221	Gold-catalysed amine synthesis by reductive hydroamination of alkynes with nitroarenes	Nat. Chem.
222	Modular alkene synthesis from carboxylic acids, alcohols and alkanes via integrated photocatalysis	Nat. Chem.
223	Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids	Nat. Chem.
224	Modular enantioselective assembly of multi-substituted boron- stereogenic BODIPYs	Nat. Chem.
225	Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction	Nat. Chem.
226	Probing the chemical ‘reactome’ with high-throughput experimentation data	Nat. Chem.
227	Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates	Nat. Chem.
228	Radical-triggered translocation of C–C double bond and functional group	Nat. Chem.
229	Repurposing of halogenated organic pollutants via alkyl bromide- catalysed transfer chlorination	Nat. Chem.
230	Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes	Nat. Chem.
231	Triazenolysis of alkenes as an aza version of ozonolysis	Nat. Chem.
232	Triplet carbenes with transition-metal substituents	Nat. Chem.
233	Tunable molecular editing of indoles with fluoroalkyl carbenes	Nat. Chem.
234	Generation and reactivity of unsymmetrical strained heterocyclic allenes	Nat. Synth.
235	Synthesis of alkenyl boronates through stereoselective vinylene homologation of organoboronates	Nat. Synth.
236	Visible-light-driven synthesis of N-heteroaromatic carboxylic acids by thiolate-catalysed carboxylation of C(sp²)–H bonds using CO2	Nat. Synth.
237	A Gram-negative-selective antibiotic that spares the gut microbiome	Nature
238	A deconstruction–reconstruction strategy for pyrimidine diversification	Nature
239	A general strategy for the synthesis of taxane diterpenes	Nature
240	A light-driven enzymatic enantioselective radical acylation	Nature
241	Alkene dialkylation by triple radical sorting	Nature
242	Asymmetric hydrogenation of ketimines with minimally different alkyl groups	Nature
243	Boron catalysis in a designer enzyme	Nature
244	Catalysis of an SN2 pathway by geometric preorganization	Nature
245	Catalytic asymmetric cationic shifts of aliphatic hydrocarbons	Nature
246	Catalytic glycosylation for minimally protected donors and acceptors	Nature
247	Computational prediction of complex cationic rearrangement outcomes	Nature
248	Continuous collective analysis of chemical reactions	Nature
249	Copper-catalysed dehydrogenation or lactonization of C(sp3)–H bonds	Nature
250	Couple-close construction of polycyclic rings from diradicals	Nature
251	Coupling of unactivated alkyl electrophiles using frustrated ion pairs	Nature
252	Direct radical functionalization of native sugars	Nature
253	Dynamic stereomutation of vinylcyclopropanes with metalloradicals	Nature
254	Electrocatalytic reductive deuteration of arenes and heteroarenes	Nature
255	Emergence of a distinct mechanism of C–N bond formation in photoenzymes	Nature
256	Hydroamination of alkenes with dinitrogen and titanium polyhydrides	Nature
257	Identifying general reaction conditions by bandit optimization	Nature
258	Photocatalytic C–F bond activation in small molecules and polyfluoroalkyl substances	Nature
259	Reductive alkyl–alkyl coupling from isolable nickel–alkyl complexes	Nature
260	Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling	Nature
261	Stereospecific alkenylidene homologation of organoboronates by SNV reaction	Nature
262	Stereospecific radical coupling with a non-natural photodecarboxylase	Nature
263	Symmetry breaking and chiral amplification in prebiotic ligation reactions	Nature
264	Synergistic photobiocatalysis for enantioselective triple-radical sorting	Nature
265	Synthesis of non-canonical amino acids through dehydrogenative tailoring	Nature
266	Unimolecular net heterolysis of symmetric and homopolar σ-bonds	Nature
267	Unlocking carbene reactivity by metallaphotoredox α-elimination	Nature
268	Asymmetric Synthesis of the cis-1,2-Diaryltetralin Vepdegestrant Core via an Enantioselective Intramolecular Corey- Chaykovsky Epoxidation	OPRD
269	Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	OPRD
270	G-EnzyBeads for Biocatalysis Screening Facilitated by Volumetric Dosing	OPRD
271	Optimization and Scale-Up Synthesis of a Lappaconitine Alkaloid Derivative, QG3030, as a Novel Osteoanabolic Agent	OPRD
272	Oxygen-, Nitrogen-, and Sulfur-Containing Heterocycles: Recent Advances in De Novo Synthesis and Prospect	OPRD
273	Practical and Efficient Approach to Scalable Synthesis of Rucaparib	OPRD
274	Process Development for the Manufacture of a Topical Pan-Trk Inhibitor Incorporating Decarboxylative sp²–sp³ Cross- Coupling	OPRD
275	Process Development to Synthesize SGD-11275 Utilizing a Pd-Catalyzed Acetamide Arylation and Gallium-Mediated Friedel–Crafts Acylation	OPRD
276	Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	OPRD
277	N-Oxide-to-Carbon Transmutations of Azaarene N-Oxides	Org. Lett.
278	Assembly of 2-Substituted Tetrahydroquinolines from ortho-Methylbenzenesulfamides and Dienes, Using a C(sp³)–H Activation/Annulation Sequence	Org. Lett.
279	C(sp³)–C(sp³) Coupling of Cycloalkanes and Alkyl Halides via Dual Photocatalytic Hydrogen Atom Transfer and Nickel Catalysis	Org. Lett.
280	Catalytic Generation of Pyridyl Radicals via Electron Donor–Acceptor Complex Photoexcitation: Synthesis of 2-Pyridylindole-Based Heterobiaryls	Org. Lett.
281	Decarboxylative Nucleophilic Fluorination of Aliphatic Carboxylic Acids	Org. Lett.
282	Diazene-Catalyzed Oxidative Alkyl Halide–Olefin Metathesis	Org. Lett.
283	Dual Function of N-Iodosuccinimide for C(sp³)–B Bond Activation	Org. Lett.
284	General Approach to Amides through Decarboxylative Radical Cross- Coupling of Carboxylic Acids and Isocyanides	Org. Lett.
285	Ground State Generation and Cyclization of Aminium Radicals in the Formation of Tetrahydroquinolines	Org. Lett.
286	Ligand-Controlled On–Off Switch of a Silicon-Tethered Directing Group Enabling the Regiodivergent Hydroalkylation of Vinylsilanes under Ni–H Catalysis	Org. Lett.
287	Nickel-Catalyzed Deoxygenative Amidation of Alcohols with Carbamoyl Chlorides	Org. Lett.
288	Photochemical Reduction of Quinolines with γ-Terpinene	Org. Lett.
289	Photoredox/Nickel Dual Catalysis-Enabled Aryl Formylation with 2,2-Dimethoxy-N,N-dimethylethan-1-amine as CO Source	Org. Lett.
290	Radical versus Non-Radical Reactivity in ortho- and para-Quinonedimethides and Implications for Cycloaddition Mechanisms	Org. Lett.
291	Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox- Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization	Org. Lett.
292	Rhodium-Catalyzed Double Dearomatization of 1,2,3-Triazole–Isoxazole Dyads: Synthesis of Nonfused 1H-1,3-Diazepines	Org. Lett.
293	Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride	Org. Lett.
294	Visible-Light-Promoted α-C(sp³)–H Amination of Ethers with Azoles and Amides	Org. Lett.
295	A decarbonylative approach to alkylnickel intermediates and C(sp ³ )-C(sp ³ ) bond formation	Science
296	A solid noncovalent organic double-helix framework catalyzes asymmetric [6 + 4] cycloaddition	Science
297	A solution to the anti-Bredt olefin synthesis problem	Science
298	Alcohol-alcohol cross-coupling enabled by S _H 2 radical sorting	Science
299	AlphaFold2 structures guide prospective ligand discovery	Science
300	Aminative Suzuki–Miyaura coupling	Science
301	An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids	Science
302	Asymmetric photoenzymatic incorporation of fluorinated motifs into olefins	Science
303	Binding and sensing diverse small molecules using shape-complementary pseudocycles	Science
304	Biocatalytic C–H oxidation meets radical cross-coupling: Simplifying complex piperidine synthesis	Science
305	Carbon quaternization of redox active esters and olefins by decarboxylative coupling	Science
306	Catalytic enantioselective reductive Eschenmoser-Claisen rearrangements	Science
307	Cobalt-catalyzed synthesis of amides from alkenes and amines promoted by light	Science
308	Differentiating enantiomers by directional rotation of ions in a mass spectrometer	Science
309	Direct propylene epoxidation via water activation over Pd-Pt electrocatalysts	Science
310	Enantioselective remote methylene C−H (hetero)arylation of cycloalkane carboxylic acids	Science
311	Expansive discovery of chemically diverse structured macrocyclic oligoamides	Science
312	Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis	Science
313	Nickel binding enables isolation and reactivity of previously inaccessible 7-aza-2,3-indolynes	Science
314	Nitrate reduction enables safer aryldiazonium chemistry	Science
315	Ph ₃ PCN ₂ : A stable reagent for carbon-atom transfer	Science
316	Photocatalytic furan-to-pyrrole conversion	Science
317	Photochemical phosphorus-enabled scaffold remodeling of carboxylic acids	Science
318	Photosensitization enables Pauson-Khand–type reactions with nitrenes	Science
319	Radical-mediated click-clip reactions	Science
320	Stereodivergent access to non-natural α-amino acids via enantio- and Z / E -selective catalysis	Science
321	Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N -heterocycles	Science
322	Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas	Science
323	Targeting cancer with small-molecule pan-KRAS degraders	Science
324	Terminal C(sp ³ )–H borylation through intermolecular radical sampling	Science
325	The sugar cube: Network control and emergence in stereoediting reactions	Science
326	Total synthesis of (−)-cylindrocyclophane A facilitated by C−H functionalization	Science
327	Visible light–mediated aza Paternò–Büchi reaction of acyclic oximes and alkenes to azetidines	Science